GPD2 — Saccharomyces cerevisiae S288c

Summary

YOL059W in Saccharomyces cerevisiae S288c encodes a cytosolic NAD-dependent glycerophosphate dehydrogenase. The gene is associated with glycerol anabolism, glycerol-3-phosphate metabolism and breakdown, and the glycerophosphate shuttle. It is linked to ethanol fermentation, mixed acid fermentation, and isobutanol anabolism, as well as D-galacturonate and valine metabolism. Associations with biomass yield, protein content, salt tolerance, and oxidative stress have been noted, along with phenotypes including decreased anaerobic growth rate, altered chemical compound accumulation, and increased or decreased chemical resistance. The gene product localizes to the cytosol and nucleus and is also found in the fungal biofilm matrix. Studies of related genes in other species link the family to turgor pressure and calcium sensitivity.