PFY1 — Saccharomyces cerevisiae S288c

Summary

YOR122C in Saccharomyces cerevisiae S288c encodes a profilin family protein, as indicated by its profilin conserved sequence and profilin domain. The product exhibits proline-rich region binding, G-actin binding, PtdIns(4,5)P2 binding, and protein sequestering activity. It is associated with numerous cellular processes including actin polymerization and depolymerization, nuclear import and transport, cytokinesis, cell cycle control, morphogenesis, secretion, mating, and pinocytosis. The protein localizes to the cytoskeleton, actin patches, the medial ring, the cell cortex, and mating projection tips. Phenotypic associations link YOR122C to abnormal actin cytoskeleton morphology, cell shape, and nuclear morphology, as well as decreased mating efficiency, autophagy, and hyperosmotic stress resistance, increased heat sensitivity and toxin resistance, and absent spore germination. The gene is also associated with oxidative stress and delayed protein secretion.