YOR290C — Saccharomyces cerevisiae S288c

Summary

YOR290C (SNF2) on chromosome XV of Saccharomyces cerevisiae S288c encodes an ATP-dependent chromatin remodeler with helicase activity, histone binding, DNA translocase activity, and H3-H4 dimer loading activity. It is associated with recombinational repair, double-strand break repair, strand invasion, postreplication repair, mitotic recombination, and nucleotide excision repair. The gene is linked to chromatin decompaction, protein-DNA complex remodeling, and regulation of ATPase activity. It localizes to the SHREC complex, PBAF complex, CHRAC, heterochromatin, and condensed chromosome centric regions. SNF2 is associated with plant height and oxidative stress traits. Phenotypic associations include absent mating type switching, increased mutation frequency, decreased gamma ray and UV resistance, absent sporulation, decreased respiratory growth, decreased hyperosmotic stress resistance, decreased chronological lifespan, and increased innate thermotolerance. Studies of related genes in other species link the family to the SWI-SNF complex.