PDR12 — Saccharomyces cerevisiae S288c

Summary

YPL058C, also known as SNQ2 or PDR12, is a gene on chromosome XVI of Saccharomyces cerevisiae S288c. It encodes an ABC-type xenobiotic transporter with ATP-coupled transmembrane transporter activity, ATP binding, and ATP hydrolase activity. The protein localizes to the plasma membrane and belongs to the ABCG/PDR family. This gene is associated with a wide range of biological processes, including detoxification, cellular response to xenobiotic stimulus, response to antibiotic, excretion, secretion, lipid metabolism, ergosterol anabolism, amino acid breakdown, the TCA cycle, and the shikimate pathway. It has been linked to traits such as drought tolerance, oxidative stress, salt tolerance, and acid sensitivity. Phenotypic associations include decreased acid pH resistance, increased chemical compound excretion, decreased resistance to chemicals, and decreased competitive fitness. Studies of related genes in other species link the family to reduced virulence.