HOS3 — Saccharomyces cerevisiae S288c

Summary

YPL116W in Saccharomyces cerevisiae S288c encodes a histone deacetylase with histone H3-K14 deacetylase activity, chromatin binding, and identical protein binding. The gene is associated with protein deacetylation, RNA stabilization, nuclear export, and epigenetic regulation of gene expression. It is linked to filamentous growth in response to pH, regulation of phenotypic switching, asexual reproduction, and sporogenesis. YPL116W is associated with salt sensitivity, oxidative stress, and cellular response to basic pH. The product localizes to the HDA1 complex, SHREC complex, euchromatin, heterochromatin islands, rDNA heterochromatin, subtelomeric heterochromatin, and the nucleolus. Phenotypic associations include decreased nuclear export, increased transposable element transposition, abnormal cell cycle progression, decreased silencing, increased mutation frequency, and altered competitive fitness. Studies of related genes in other species link the family to histone deacetylase activity (EC 3.5.1.98).