RAD53 — Saccharomyces cerevisiae S288c

Summary

YPL153C (RAD53, also known as cds1) on chromosome XVI of Saccharomyces cerevisiae S288c encodes a protein with protein serine/threonine kinase activity, Ca2+/CaM-dependent kinase activity, protein kinase A activity, calmodulin binding, and phospholipid binding. The gene is associated with DNA damage checkpoint, cell cycle control (including G2 phase and mitotic checkpoint), establishment of sister chromatid cohesion, non-homologous end joining, regulation of homologous recombination, and regulation of telomere maintenance. It is linked to response to chemical, cellular response to MMS, response to doxorubicin, glycerolipid anabolism, and mitochondrial gene expression. The protein localizes to the nuclear membrane, vacuolar membrane, mitotic spindle pole body, and cellular bud neck. Phenotypic associations include decreased UV resistance, decreased X-ray resistance, increased apoptosis, decreased replicative lifespan, decreased chronological lifespan, abnormal cell cycle progression, and decreased competitive fitness.