MLH3 — Saccharomyces cerevisiae S288c

Summary

YPL164C (MLH3) on chromosome XVI of Saccharomyces cerevisiae encodes a protein with ATP hydrolase activity, ATP binding, and mispair binding, placing it in the MutL family of DNA mismatch repair proteins. The gene is associated with meiotic mismatch repair, meiotic metaphase I, prophase, meiosis I, regulation of mismatch repair, DNA damage checkpoint, removal of nonhomologous ends, maintenance of DNA repeat elements, resolution of meiotic recombination intermediates, heteroduplex formation, meiotic gene conversion, and mating behavior. It localizes to the MLH1/PMS2 complex, nuclear chromosome, mitotic spindle pole body, cytosol, and nucleus. Phenotypic associations include decreased spore germination, normal or decreased sporulation, increased mutation frequency, increased replicative lifespan, haploinsufficiency, increased competitive fitness, abnormal vacuolar morphology, and decreased chemical resistance.