MRN1 — Saccharomyces cerevisiae S288c

Summary

YPL184C, also known as MRN1, on chromosome XVI of Saccharomyces cerevisiae S288c, encodes an RNA-binding protein containing an Mrn1_RRM1 domain and a Cwc2/Slt11-related domain. The protein binds poly(U) and mRNA, and is localised to the cytoplasm, cytosol, and stress granules. MRN1 is associated with a wide range of biological processes, including transcriptional attenuation, nuclear RNA surveillance, mRNA destabilization, ribosome biogenesis, the DNA damage response, and signal transduction. It is also linked to cellular responses to nutrients and yeast. Phenotypically, MRN1 has been connected to altered stress resistance, including increased innate thermotolerance and toxin resistance, but decreased resistance to UV, hyperosmotic stress, oxidative stress, and metals. Other associations include decreased replicative lifespan, abnormal colony appearance and vacuolar morphology, and altered competitive fitness and vegetative growth.