ATG11 — Saccharomyces cerevisiae S288c

Summary

YPR049C, also known as ATG11, encodes a protein that binds SNAREs, protein kinases, and acts as a bridging scaffold. It is a core component of the ULK complex and localises to the phagophore assembly site (PAS) membrane and the vacuolar membrane. ATG11 is associated with numerous autophagy-related processes, including mitophagy, nucleophagy, ER-phagy, microautophagy, and Cvt vesicle assembly, as well as cargo selection, vesicle formation, membrane fission, and organelle disassembly. It is also linked to cell cycle events such as spindle positioning, chromosome biorientation, and the spindle assembly checkpoint. Phenotypic associations include absent or decreased autophagy and mitophagy, abnormal nucleophagy, absent pexophagy, decreased sporulation and viability, increased cell death, and altered oxidative stress resistance. The gene is further associated with biomass yield and oxidative stress.