CLB2 (YPR119W) — Saccharomyces cerevisiae S288c

Summary

YPR119W (CLB2) on chromosome XVI of Saccharomyces cerevisiae encodes a cyclin, a member of the cyclin family characterized by cyclin-box and cyclin N/C domains. The gene product possesses cyclin-dependent protein serine/threonine kinase activator and regulator activities, and is associated with protein kinase activity. CLB2 is linked to numerous cell cycle processes, including mitotic cell cycle phase transitions, spindle assembly and breakdown, metaphase, mitotic exit, and nuclear division. It has also been linked to DNA recombination, programmed cell death, protein kinase A signaling, and regulation of spore germination. The protein localizes to the CDK holoenzyme, mitotic and meiotic spindles, microtubule-organizing centers, and the nuclear periphery. Phenotypic associations include altered cell cycle progression (G2/M phase transition duration increased, G1 phase duration decreased), increased cell size, abnormal budding and cell shape, increased filamentous and invasive growth, decreased thermotolerance and UV resistance, and increased replicative lifespan.