NTG1 — Saccharomyces cerevisiae S288c

Summary

YAL015C (NTG1) in Saccharomyces cerevisiae S288c encodes a protein with 5-hmU DNA N-glycosylase, 8-oxoG DNA N-glycosylase, and AP site-DNA 5'-phosphomonoester-lyase activities, and binds a 4Fe-4S cluster. The protein localises to the mitochondrial lumen and nucleus. It is associated with base excision repair, postreplication repair, homologous recombination, DNA double-strand break processing, rolling circle replication, mtDNA replication, and mRNA breakdown. The gene has been linked to response to freezing, regulation of carbohydrate metabolism, maltose metabolism, nitric oxide storage, and protein modification. Phenotypic associations include abnormal mutation frequency and mitochondrial genome maintenance, increased mutation frequency, decreased UV resistance and heat sensitivity, altered chemical compound accumulation, and changes in competitive fitness. The gene is also linked to carbohydrate content and oxidative stress traits. Studies of related genes in other species place the family in DNA damage repair pathways.