CLN3 — Saccharomyces cerevisiae S288c

Summary

YAL040C in Saccharomyces cerevisiae S288c encodes a cyclin, a protein that possesses cyclin-dependent protein serine/threonine kinase regulator activity and protein kinase activity. It is a component of the CDK holoenzyme and localises to the cytoplasm, cytosol and nucleus. The gene is associated with cell cycle control, particularly G1 phase progression and the G1 cell-size checkpoint, as well as mitotic cell cycle, cell morphogenesis, pseudohyphal growth, cell-cell adhesion, lipid storage, glycolytic fermentation, ethanol fermentation, ribosome assembly, and response to peptide. It is linked to traits including calcium sensitivity, protein content, and oxidative stress. Phenotypic associations include altered cell size, nucleus size, pheromone sensitivity and cell cycle arrest, abnormal lipid particle and mitochondrial morphology, and changes in mating and sporulation efficiency, apoptosis, and mutation frequency. Studies of related genes in other species link the cyclin family to cell cycle regulation.