ATG8 — Saccharomyces cerevisiae S288c

Summary

YBL078C (ATG8) on chromosome II of Saccharomyces cerevisiae encodes a phosphatidylethanolamine-binding protein that also functions as a protein tag. The gene is associated with a broad range of autophagy-related processes, including microlipophagy, micropexophagy, nucleophagy, ER-phagy, and regulation of autophagy, as well as cargo selection, membrane fission, and protein targeting to the vacuole. It is linked to cellular senescence, homeostasis, sulfite efflux, deubiquitination, and the osmotic response. The protein localizes to the Cvt vesicle membrane, vacuole-IM contact sites, cytoplasmic vesicles, the phagophore assembly site (PAS), adiposomes, mitochondrial and vacuolar membranes, and the cytosol. Phenotypic associations include absent or decreased autophagy, pexophagy, mitophagy, and nucleophagy, abnormal vacuolar transport and morphology, decreased viability, sporulation, and replicative lifespan, and altered stress resistance and metal resistance.