GAL10 — Saccharomyces cerevisiae S288c

Summary

YBR019C in Saccharomyces cerevisiae S288c encodes a protein with UDP-glucose 4-epimerase and aldose 1-epimerase activities, and is also associated with sugar binding. The gene is linked to the Leloir pathway and galactose metabolism, as well as processes including lysine breakdown, ribosomal skipping, platelet aggregation, receptor breakdown, xenobiotic metabolism, carbohydrate anabolism, starch breakdown, fruit development, oxidative phosphorylation, cytochrome anabolism, monosaccharide metabolism, lactose metabolism, UDP-galactose biosynthesis, response to host, fructose uptake, and transcriptional readthrough. It localises to the cytosol and extracellular space. Associations with traits include herbicide sensitivity, copper concentration, biomass yield, salt tolerance, and oxidative stress. Phenotypic associations include absent or decreased carbon source utilization, decreased endocytosis, decreased protein accumulation, absent respiratory growth, decreased nitrogen source utilization, decreased vegetative growth, abnormal vacuolar morphology, decreased competitive fitness, and decreased chemical resistance. Studies of related genes in other species link the family to UDP-glucose 4-epimerase and aldose 1-epimerase activities.