CYC8 — Saccharomyces cerevisiae S288c

Summary

YBR112C in Saccharomyces cerevisiae S288c encodes a protein with chromatin DNA binding, transcription corepressor activity, and RNA polymerase II cis-regulatory region sequence-specific DNA binding. The protein is a component of the transcription repressor complex and the Tup11/Tup12 repressor complex, localizing to the nucleus, cytoplasm, and chromatin. It is associated with diverse biological processes including D-xylose and maltose metabolism, glycerol anabolism, the ER stress response, flocculation and its regulation, pseudohyphal growth, sumoylation, the TCA cycle, the glucose effect, translation initiation, nuclear export, amino acid anabolism, glycogen metabolism regulation, glycoprotein breakdown, and the response to hypoxia. The gene has been linked to traits such as salt tolerance, potassium concentration, biomass yield, protein content, and oxidative stress. Phenotypic associations include altered nutrient uptake, carbon source utilization, flocculation, cell shape and budding pattern, sporulation, telomere length, growth rate, and resistance to toxins, metals, and oxidative stress.