TPS1 — Saccharomyces cerevisiae S288c

Summary

YBR126C, also known as TPS1, encodes a protein with trehalose-phosphatase, trehalose synthase, and transglucosylase activities, and is a component of the trehalose-6-phosphate synthase complex localised to the cytosol. The gene is associated with trehalose biosynthesis and catabolism, glycogen metabolism, lipid storage, and responses to glucose, ethanol, heat, freezing, and nutrient levels. It is linked to numerous phenotypes including decreased viability, sporulation, spore germination, pseudohyphal growth, fermentative and respiratory growth, and resistance to acid, hyperosmotic stress, desiccation, and oxidative stress, as well as increased resistance to enzymatic treatment and metal resistance. Associations with traits such as starch content, drought tolerance, biomass yield, and stomatal resistance have also been noted. Studies of related genes in other species link the family to reduced virulence.