MEC1 — Saccharomyces cerevisiae S288c

Summary

YBR136W (MEC1) on Saccharomyces cerevisiae chromosome II encodes a protein with protein serine/threonine kinase activity, histone H2A kinase activity, and ATP binding. It is a member of the PIK-related kinase family and localises to the nucleus, nucleolus, chromatin, telomeric regions and the ATR-ATRIP complex. MEC1 is associated with DNA damage checkpoint signalling, replication fork arrest, DNA recombination, telomere maintenance, nucleotide excision repair, sumoylation, meiotic DNA double-strand break formation, and the response to heat. It is linked to numerous phenotypes including decreased viability, increased heat and cold sensitivity, increased apoptosis, decreased chronological lifespan, increased mutation frequency, decreased telomere length, altered mitotic and meiotic recombination, and altered resistance to UV, ionising radiation, chemicals and toxins. The gene is also connected to respiration rate and oxidative stress.