ALG7 — Saccharomyces cerevisiae S288c

Summary

YBR243C in Saccharomyces cerevisiae S288c encodes a UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, with transglycosidase activity and metal binding. This gene is associated with protein glycosylation, oligosaccharide-PP-dolichol assembly, GPI anchor anabolism, and dolichol anabolism, as well as the G1/G0 transition, spore germination, embryo sac development, syngamy, nitric oxide signaling, and cellular homeostasis. It localizes to the ER membrane and the UDP-N-acetylglucosamine transferase complex. Phenotypic associations include inviability, haploid insufficiency, abnormal mitochondrial genome maintenance, absent sporulation, decreased protein/peptide modification, altered toxin and chemical resistance, decreased competitive fitness, and decreased chemical compound accumulation. Studies of related genes in other species link the family to EC 2.7.8.15 activity.