SSH1 — Saccharomyces cerevisiae S288c

Summary

YBR283C (SSH1) in Saccharomyces cerevisiae S288c on chromosome II encodes a protein with peptide transmembrane transporter activity, signal sequence binding, protein translocase activity, and ribosome binding. It is associated with the ER membrane and extracellular vesicles. The gene is linked to numerous biological processes including SRP-dependent cotranslational membrane targeting and translocation, posttranslational protein membrane targeting, protein-ER insertion, misfolded protein transport, glycosylation, ergosterol anabolism, and lipogenesis. Associations with traits include amino acid content and oxidative stress. Phenotypic associations include increased mitophagy and telomere length, abnormal ER morphology, decreased fermentative and respiratory growth, increased oxidative stress resistance, decreased desiccation and toxin resistance, altered vegetative growth, and altered competitive fitness. Studies of related genes in other species link the family to the Sec61 translocon complex.