MRC1 — Saccharomyces cerevisiae S288c

Summary

YCL061C in Saccharomyces cerevisiae S288c encodes a member of the Claspin family characterized by the Repl_chkpnt_MRC1 domain. The gene is associated with a wide range of biological processes, including establishment of sister chromatid cohesion, DNA metabolism, protein phosphorylation, telomere maintenance, DNA damage checkpoint signaling, homologous recombination, and circadian rhythm. It is also linked to signal transduction and the response to cisplatin. Phenotypic associations include increased cell size, decreased replicative lifespan, increased mutation frequency, altered telomere length, increased biofilm formation, and decreased stress resistance, including heat sensitivity and desiccation resistance. The gene is further connected to traits such as protein content, light sensitivity, and oxidative stress, as well as altered cell cycle progression, including delayed G1/S phase transition and increased S phase duration.