MSH3 — Saccharomyces cerevisiae S288c

Summary

YCR092C (MSH3) in Saccharomyces cerevisiae S288c on chromosome III encodes a member of the MutS family of DNA mismatch repair proteins, characterized by DNA_mismatch_repair_MutS_clamp and related domains. The gene product exhibits heteroduplex DNA loop binding, mispair binding, Y-form DNA binding, and ATP-dependent DNA damage sensor activity. MSH3 is associated with mitotic and meiotic recombination, mismatch repair (MMR), nucleotide excision repair (NER), the DNA damage checkpoint, removal of nonhomologous ends, maintenance of DNA repeat elements, heteroduplex formation, gene conversion at the mating-type locus, mitochondrial DNA repair, and error-free post-replication repair. It localizes to the nucleus and sites of double-strand breaks. Phenotypic associations include increased chromosome/plasmid maintenance and mutation frequency, decreased mitotic recombination and acid pH resistance, abnormal vacuolar morphology, and decreased competitive fitness. Related genes in other species are linked to the MutSbeta complex.