RPN4 — Saccharomyces cerevisiae S288c

Summary

YDL020C, also known as RPN4, is a gene on chromosome IV of Saccharomyces cerevisiae S288c that encodes a DNA-binding transcription activator with RNA polymerase II-specific activity, belonging to the C2H2-type zinc finger protein family. The product is localized to the nucleus. RPN4 is associated with a wide range of biological processes, including proteolysis, protein breakdown, DNA damage response, double-strand break repair, homologous recombination, regulation of autophagy, cell cycle modulation, calcium signaling, lipid metabolism, and detoxification. It has been linked to traits such as calcium sensitivity, oxidative stress, and light sensitivity. Phenotypic associations include altered cell cycle progression, decreased acquired thermotolerance, increased prion formation, decreased telomere length, and changes in replicative lifespan, stress resistance, and toxin resistance. Studies of related genes in other species further connect the family to stress responses.