SIT4 — Saccharomyces cerevisiae S288c

Summary

YDL047W in Saccharomyces cerevisiae S288c encodes a protein serine/threonine phosphatase with metal-binding activity, belonging to the PP2A-like family and the calcineurin-like phosphatase superfamily. It is a component of the protein phosphatase 4 complex and the PP2A complex, localizing to the nucleus, cytoplasm, cytosol, chromatin, and nuclear periphery. The gene is associated with a wide range of biological processes including TOR signaling, the MAPK cascade, gluconeogenesis, cell wall biogenesis, membrane biogenesis, lipolysis, lipogenesis, glycogen anabolism, lipid A anabolism, amino acid import, cytosolic transport, protein localization, protein phosphorylation, response to nutrient, ceramide, and TNF, as well as cellular senescence and cell morphogenesis. Phenotypically, YDL047W is linked to abnormal fermentative and respiratory metabolism, increased apoptosis and biofilm formation, decreased telomere length and replicative lifespan, altered stress responses including increased osmotic stress resistance and increased cold sensitivity, and abnormal morphology of mitochondria, endoplasmic reticulum, lipid particles, and the actin cytoskeleton. It is also associated with traits such as salt sensitivity, oxidative stress, and light sensitivity. Studies of related genes in other species link the family to reduced virulence.