CDC53 — Saccharomyces cerevisiae S288c

Summary

YDL132W (CDC53, cul1) on chromosome IV of Saccharomyces cerevisiae S288c encodes a cullin family protein. The gene product possesses IP6 binding, ubiquitin ligase binding, and protein binding, bridging activities. It is associated with cell cycle control, meiotic cell cycle control, MAPK cascade, mitochondrial fusion, cell wall organization, leaf senescence, photomorphogenesis, pollination, flower morphogenesis, and bioluminescence. The protein localizes to the cytosol, nucleus, and several ubiquitin ligase complexes including the Cul4-RING E3 complex. The gene is linked to traits including self-incompatibility and oxidative stress. Phenotypic associations include abnormal cell size and morphology, G1 phase cell cycle arrest, altered heat sensitivity, increased toxin resistance, decreased vegetative growth, and inviability. Related genes in other species are associated with nuclear SCF complex localization.