CDC13 — Saccharomyces cerevisiae S288c

Summary

YDL220C, also known as CDC13, encodes a telomere end-binding protein in Saccharomyces cerevisiae S288c on chromosome IV. The product belongs to the POT1/Cdc13 family and contains OB-fold nucleic-acid-binding domains. CDC13 is associated with telomere capping, telomere maintenance, and its regulation, as well as mitotic recombination, DNA damage checkpoint response, double-strand break repair, and telomeric silencing. It is linked to cell cycle processes including G2 phase, M phase, nuclear division, spindle pole body separation, and mitotic spindle positioning. Phenotypic associations include altered telomere length (both increased and decreased), decreased lifespan, increased apoptosis, cell cycle arrest in G2, abnormal budding index, increased chitin deposition, increased mitotic recombination, decreased viability, absent sporulation, increased cell size, abnormal cellular morphology, decreased UV and heat resistance, altered metal and chemical resistance, and changes in vegetative growth and competitive fitness.