DBF4 — Saccharomyces cerevisiae S288c

Summary

YDR052C in Saccharomyces cerevisiae S288c encodes a protein with protein kinase activator activity and nucleic acid binding, and it contains zinc finger and BRCT domains. The gene is associated with positive regulation of DNA replication initiation, MCM complex loading, mitotic cell cycle progression, and cytokinesis. It is linked to the DDK complex and localizes to the nucleus, nucleoplasm, and mitotic spindle pole body. Phenotypic associations include arrested or abnormal S-phase progression, increased cold and heat sensitivity, altered protein modification and accumulation, and changes in chemical and toxin resistance. The gene is also associated with oxidative stress and shows increased competitive fitness under certain conditions. Studies of related genes in other species link the family to similar cell cycle regulatory roles.