CDC34 — Saccharomyces cerevisiae S288c

Summary

YDR054C (CDC34) on chromosome IV of Saccharomyces cerevisiae S288c encodes a protein with ubiquitin-conjugating enzyme activity, SUMO conjugating enzyme activity, ssDNA-dependent ATPase activity, and proteasome binding. The gene is associated with cell cycle control, particularly G1 phase progression and centrosome duplication, as well as the MAPK cascade, cell wall organization, transposition, and the stress-induced INMAD pathway. It localizes to multiple ubiquitin ligase complexes including the Rad6-Rad18 complex, heterochromatin, and telomeric regions. Phenotypic associations link CDC34 to abnormal redox state, decreased telomere length, altered heat sensitivity and oxidative stress resistance, and impaired vegetative growth. Studies of related genes in other species connect the family to EC 2.3.2.23.