SSY1 — Saccharomyces cerevisiae S288c

Summary

YDR160W, also known as SSY1 and CAN1 on chromosome IV of Saccharomyces cerevisiae S288c, encodes an amino acid permease with L-proline and L-arginine transmembrane transporter activity. The gene is associated with amino acid import, response to amino acids, and regulation of proline and arginine metabolism, as well as cellular amino acid homeostasis. It has been linked to processes including retrotransposition, non-homologous end joining, sphingolipid anabolism, exocyst assembly, and nuclear import. The encoded protein localizes to the plasma membrane, eisosome, fungal-type cell wall, Golgi membrane, and endoplasmic reticulum. Associations with traits include amino acid content, potassium uptake, acid sensitivity, and oxidative stress. Phenotypic associations include altered transposable element transposition, metal resistance, chromosome maintenance, competitive fitness, and chemical resistance. Studies of related genes in other species link the family to general amino acid transport.