UBC1 — Saccharomyces cerevisiae S288c

Summary

YDR177W in Saccharomyces cerevisiae S288c encodes a protein with ubiquitin conjugating enzyme activity, ubiquitin-protein transferase activity, ubiquitin ligase activity, proteasome binding, and ATP binding. It is localized to the cytoplasm, cytosol, and nucleus. The gene is associated with numerous biological processes, including protein polyubiquitination, K63-linked ubiquitination, regulation of the mitotic metaphase/anaphase transition, spindle checkpoint effector process, anaphase, G0 to G1 transition, vacuolar transport, dephosphorylation, cytoplasm-to-vacuole targeting, proteasome degradation, SCF-dependent proteasomal ubiquitin-dependent protein breakdown, peroxisome matrix protein import, and protein quality control. Phenotypic associations include altered innate thermotolerance, heat sensitivity, toxin resistance, chromosome/plasmid maintenance, competitive fitness, and chemical resistance, as well as inviability and haploinsufficiency. Studies of related genes in other species link the family to ubiquitin-conjugating enzyme activity (EC 2.3.2.23).