SCC2 — Saccharomyces cerevisiae S288c

Summary

YDR180W encodes a protein with cohesin loader activity, ATPase activator activity, and kinetochore binding, and is a member of the Scc2/Nipped-B family. The gene is associated with the establishment of mitotic sister chromatid cohesion, sister chromatid segregation, metaphase and anaphase progression, chromatin looping, heterochromatin organization, rDNA packaging, centromere clustering, tRNA gene clustering, and transcription-dependent tethering of RNA polymerase II genes at the nuclear periphery. It is linked to decreased oxidative stress resistance, increased heat sensitivity, abnormal nucleolar morphology, increased mitotic recombination, and decreased chromosome/plasmid maintenance. The protein localizes to the SMC loading complex, the Mis4-Ssl3 cohesin loading complex, chromatin, and the nucleus. Related genes in other species connect the family to sister chromatid cohesion.