SKP1 — Saccharomyces cerevisiae S288c

Summary

YDR328C (SKP1) on chromosome IV of Saccharomyces cerevisiae encodes a protein with annotated molecular functions including cullin family protein binding, ubiquitin ligase activity, glutathione binding, and DNA replication origin binding. The protein localises to the nucleus, cytoplasm, kinetochore, CBF3 complex, and RAVE complex. SKP1 is associated with SCF-dependent proteasomal ubiquitin-dependent protein breakdown, regulation of proteolysis, mitochondrial fusion, posttranscriptional gene silencing by RNA, ABA signalling, and the Wg signalling pathway. It has been linked to cell cycle progression through G2/M and G1 phases, chromosome maintenance, cellular morphology, and responses to chemicals. Associations with flower morphogenesis, petal development, organ identity, and self-incompatibility are also noted. Studies of related genes in other species link the family to oxidative stress.