ARO10 — Saccharomyces cerevisiae S288c

Summary

YDR380W (ARO10) encodes a pyruvate decarboxylase with thiamine pyrophosphate and magnesium binding activity, belonging to the TPP_PYR_PDC_IPDC-like enzyme family. In Saccharomyces cerevisiae, this gene is associated with the Ehrlich pathway for aromatic amino acid catabolism to alcohols, as well as valine and tryptophan breakdown, isobutanol and 1-butanol biosynthesis, and alcohol metabolism. It has been linked to quorum sensing, biofilm formation, rhythmic behavior, protein hydroxylation, NADPH regeneration, and the shikimate pathway. The encoded product localizes to the cytosol, plasma membrane, nucleus, yeast-form and hyphal cell walls, and the fungal biofilm matrix. Phenotypic associations include increased adhesion and competitive fitness, decreased biofilm formation and starvation resistance, altered chemical compound accumulation and excretion, and modified toxin and chemical resistance. Studies of related genes in other species link the family to EC 4.1.1.1 activity.