CAN1 — Saccharomyces cerevisiae S288c

Summary

YEL063C in Saccharomyces cerevisiae S288c encodes a basic amino acid permease, a transmembrane transporter with activity for L-histidine, L-arginine, and L-lysine, and belongs to the fungal amino acid permease family. The gene is associated with the plasma membrane and eisosome, and is linked to the transport of lysine, arginine, and fatty acids, as well as to proline metabolism, DNA metabolism, actin polymerization, biofilm formation, and the response to doxorubicin and DNA damage. Associations with traits include oxidative stress and acid sensitivity. Phenotypic connections include increased flocculation, altered biofilm formation, increased chronological and replicative lifespan, decreased endocytosis, and altered stress resistance, nutrient uptake, and vegetative growth. Studies of related genes in other species link the family to arginine and lysine transport.