RAD51 — Saccharomyces cerevisiae S288c

Summary

YER095W in Saccharomyces cerevisiae S288c encodes a protein with recombinase activity, ATP-dependent DNA damage sensor activity, ATP hydrolase activity, and ATPase activity acting on DNA, and it binds single- and double-stranded DNA, identical proteins, and the Sae3-Mei5 complex. The gene is associated with homologous recombination, recombinational repair, non-homologous end joining, base excision repair, postreplication repair, DNA recombination, and the spindle assembly checkpoint. It is linked to cell cycle phases including mitotic S phase and G2 phase, as well as programmed cell death, execution phase of apoptosis, cell killing, and response to oxidative stress. The protein localises to the nucleus, cytosol, chromatin, nuclear envelope, condensed nuclear chromosome, mitochondrial chromosome, centromere complex, site of double-strand break, and the CX3 complex. Phenotypic associations include decreased resistance to UV, X-ray, gamma-ray, and oxidative stress, decreased spore germination, sporulation, and fermentative growth, increased meiotic recombination and transposable element transposition, and altered replicative and chronological lifespan.