COM2 — Saccharomyces cerevisiae S288c

Summary

YER130C (also known as COM2) in Saccharomyces cerevisiae S288c encodes a C2H2-type zinc-finger protein with DNA-binding transcription factor activity and sequence-specific DNA binding for RNA polymerase II cis-regulatory regions. The gene is associated with malate secretion, ethanal metabolism, pyridine nucleotide anabolism, sphingolipid anabolism, methionine breakdown, and upregulation of cellular response to oxidative stress. It is also linked to responses to anoxia, acetaldehyde, acetate, and nitrosative stress, as well as developmental growth, dedifferentiation, ascus development, regulation of sporulation, and glucoside transport. The encoded protein localises to the nucleus, cytoplasm, cytosol, chromatin, and the Tec1p-Ste12p-Dig1p and Ste12p-Dig1p-Dig2p complexes. Associations with traits include glucose content, calcium sensitivity, light sensitivity, and oxidative stress, while phenotypes linked to the gene include decreased endocytosis, auxotrophy, decreased UV and metal resistance, altered competitive fitness, and abnormal vacuolar morphology.