GLC7 — Saccharomyces cerevisiae S288c

Summary

YER133W in Saccharomyces cerevisiae S288c encodes a protein with RNA polymerase II C-terminal domain T4 phosphatase activity and broader protein serine/threonine phosphatase activity, characteristic of a PP1 catalytic subunit. The gene is associated with glycogen and glucose metabolism, replication fork processing and arrest, spindle assembly checkpoint, chromosome segregation regulation, and positive regulation of clathrin-mediated endocytosis. It localises to the cellular bud neck septin collar, DPS complex, PTW/PP1 phosphatase complex, and protein phosphatase type 1 complex. The gene is linked to salt and calcium sensitivity, oxidative stress, and numerous phenotypes including abnormal cell cycle progression, spindle morphology, actin cytoskeleton, decreased silencing, increased cold sensitivity, altered thermotolerance, and reduced vegetative growth and competitive fitness. Studies of related genes in other species link the family to phosphatase activity and lethal phenotypes.