RAD24 — Saccharomyces cerevisiae S288c

Summary

YER173W (RAD24) on chromosome V of Saccharomyces cerevisiae S288c encodes a DNA clamp loader with ATP hydrolase activity that also binds chromatin. The gene is associated with the DNA damage checkpoint, double-strand break repair, postreplication repair, nucleotide excision repair, homologous recombination, replication fork processing, sister chromatid cohesion, regulation of telomere maintenance, sumoylation, transposition, spore wall biogenesis, and responses to MMS and other chemicals. It localises to the nucleus, chromatin, and telomeric repeat regions. Phenotypic associations include decreased gamma ray and UV resistance, increased meiotic recombination and mutation frequency, abnormal chromosome maintenance, altered competitive fitness, and changes in resistance to chemicals and enzymatic treatment. The gene also links to cell membrane stability and oxidative stress. Studies of related genes in other species connect the family to the AAA+ ATPase domain and calcium sensitivity.