RIM15 — Saccharomyces cerevisiae S288c

Summary

YFL033C, also known as CEK1 or RIM15 in Saccharomyces cerevisiae S288c on chromosome VI, encodes a protein serine/threonine kinase with ATP-binding and identical protein-binding activities. This gene is associated with cell quiescence, the externalization of phosphatidylserine, glutamate and glycerol anabolism, the glyoxylate cycle, gluconeogenesis, the pentose-phosphate shunt, and responses to starvation, heat, trehalose, and rapamycin. It is linked to cellular homeostasis, developmental processes, heterotrophy, protein phosphorylation, nuclear import, and nuclear division. The protein localizes to the serine/threonine protein kinase complex, hyphal tip, growing cell tip, cytoskeleton, cellular bud tip, cross wall, mating projection tip, cellular bud neck, incipient cellular bud site, and cell cortex. Phenotypic associations include increased chronological lifespan, increased resistance to oxidative stress and metals, decreased sporulation and autophagy, and altered cell cycle progression. Related genes in other species link the family to protein kinase activity.