RPN11 — Saccharomyces cerevisiae S288c

Summary

YFR004W in Saccharomyces cerevisiae S288c encodes a metallopeptidase with deNEDDylase and metal-dependent deubiquitinase activities, and it binds the proteasome. The gene is associated with organelle fission, including peroxisome, mitochondrial, and membrane fission, as well as proteasome assembly and storage granule formation. It is linked to protein degradation, deneddylation, neddylation, and regulation of telomere maintenance. The protein localizes to the CSN complex, proteasome regulatory particle lid subcomplex, nucleus, cytoplasm, and mitochondria. Phenotypic associations include increased cell size, decreased vegetative growth and survival in stationary phase, increased heat sensitivity, decreased UV resistance, abnormal mitochondrial and peroxisomal distribution, and altered competitive fitness and chemical resistance. Studies of related genes in other species link the family to metallopeptidase activity.