CDH1 (YGL003C) — Saccharomyces cerevisiae S288c

Summary

YGL003C in Saccharomyces cerevisiae S288c encodes a WD40-repeat-containing protein of the Cdc20/Fizzy family with ubiquitin ligase activator activity and APC binding, and also binds GTP. The gene is associated with centrosome separation, spindle assembly, the spindle assembly checkpoint, metaphase and telophase, mitotic exit, meiosis I and II metaphase/anaphase transitions, positive regulation of anaphase-promoting complex-dependent catabolic process, regulation of proteolysis, programmed cell death, ribosome assembly, nuclear import, and gene conversion. It localises to the nucleus, kinetochore, mitotic spindle, mitotic spindle pole body, MCC, cyclosome, and cell division site. Phenotypic associations include abnormal cell cycle progression, M phase arrest, decreased cytokinesis, abnormal septum formation, decreased cell size, altered invasive and filamentous growth, increased telomere length, and altered stress resistance including decreased resistance to UV, hyperosmotic stress, heat, metal, and alkaline pH, as well as increased toxin resistance.