PMA1 — Saccharomyces cerevisiae S288c

Summary

YGL008C in Saccharomyces cerevisiae S288c encodes a P-type ATPase, specifically a proton-transporting ATPase with proton binding and ATP hydrolase activity, and is also associated with ABC-type manganese transporter activity and calcium ion binding. The gene is linked to a wide range of cellular processes including cell wall biogenesis, TOR signaling, pH regulation, membrane polarization, water and sucrose transport, and potassium ion export. It has been connected to traits such as manganese and potassium concentration, sugar content, salt sensitivity, and oxidative stress. Phenotypic associations include increased ionic stress resistance, altered killer toxin resistance, decreased innate thermotolerance, increased replicative lifespan, and absent respiratory growth. The protein localizes to the plasma membrane, endoplasmic reticulum, Golgi, and nuclear envelope. Studies of related genes in other species link the family to proton pumping and cation transport.