CDC20 — Saccharomyces cerevisiae S288c

Summary

YGL116W in Saccharomyces cerevisiae S288c encodes a protein with ubiquitin ligase activator activity and APC binding, and belongs to the Cdc20/Fizzy family containing WD40 repeats. The gene is associated with the spindle assembly checkpoint, meiotic exit, and progression through M phase, telophase, and meiosis II. It localizes to the mitotic spindle pole body, kinetochore, cyclosome, and cell division site. YGL116W is linked to chromosome segregation, cell cycle arrest, sporulation defects, and increased heat sensitivity. Associations with biomass yield and oxidative stress have also been noted. Studies of related genes in other species connect the family to spliceosome components and cell cycle regulation, though these functions are not established for YGL116W itself.