XRN1 — Saccharomyces cerevisiae S288c

Summary

YGL173C in Saccharomyces cerevisiae S288c encodes a protein with 5'-3' RNA exonuclease activity, RNA nuclease activity, recombinase activity, and microtubule binding, and it belongs to the 5_3_exoribonuclease family. The gene is associated with NAD-cap decapping, RNA and mRNA breakdown, karyogamy, spindle pole body assembly, ribosome assembly, transcription by RNA polymerase II, and response to iron. It localizes to the TXT complex, Las1 complex, P body, stress granule, cytoplasm, cytosol, and nucleus. Phenotypic associations include decreased viability, decreased fermentative and respiratory growth, increased autophagy, increased mutation frequency, abnormal cell shape and bud morphology, decreased telomere length, decreased resistance to alkaline pH and hyperosmotic stress, and altered RNA and protein accumulation. Studies of related genes in other species link the family to reduced virulence and oxidative stress.