ATG1 — Saccharomyces cerevisiae S288c

Summary

YGL180W in Saccharomyces cerevisiae S288c encodes a protein with protein serine kinase activity, protein serine/threonine kinase activity, and ATP binding, and belongs to the Atg1-like family. The gene is associated with numerous autophagy-related processes, including chaperone-mediated autophagy, lipophagy, mitophagy, ER-phagy, microautophagy, and regulation of macroautophagy. It is also linked to the externalization of phosphatidylserine, response to starvation, meiotic chromosome segregation, and developmental processes. The protein localizes to the phagophore assembly site (PAS), the ULK complex, and vacuole-IM contact sites. Phenotypic associations include absent or decreased autophagy, decreased colony size, viability, and replicative lifespan, as well as abnormal cell shape, nuclear morphology, and lipid particle morphology. The gene is further associated with nitrogen and sugar content, oxidative stress, and decreased sporulation efficiency. Related genes in other species link the family to protein serine/threonine kinase activity (EC 2.7.11.1).