MIG2 — Saccharomyces cerevisiae S288c

Summary

YGL209W, also known as MIG1 and MIG2 on chromosome VII of Saccharomyces cerevisiae S288c, encodes a C2H2-type zinc finger DNA-binding transcription factor. This protein is associated with the regulation of carbon utilization, the glucose effect, and the downregulation of transcription from the RNA polymerase II promoter by glucose. It is linked to mitochondrion distribution, pexophagy, macroautophagy, and the upregulation of the ER stress response. The gene has been connected to traits including biomass yield, carbohydrate content, protein content, carotenoid content, calcium sensitivity, and oxidative stress. Phenotypic associations include increased protein activity, increased invasive growth, increased replicative lifespan, decreased starvation resistance, decreased vegetative growth rate, and decreased resistance to chemicals. Studies of related genes in other species link the family to increased virulence.