BUB1 — Saccharomyces cerevisiae S288c

Summary

YGR188C in Saccharomyces cerevisiae S288c encodes a protein with protein serine/threonine kinase activity, histone H2AS121 kinase activity, and ubiquitin ligase inhibitor activity. The gene product is a component of the Bub1-Bub3 complex and the mitotic checkpoint complex (MCC), localizing to kinetochores, centromeres, and spindle pole bodies. YGR188C is associated with chromosome biorientation, spindle assembly checkpoint, mitotic and meiotic chromosome segregation, and metaphase/anaphase transition regulation. The gene is linked to numerous phenotypes including decreased viability, abnormal spindle morphology, premature anaphase progression, and altered stress responses such as increased oxidative stress resistance but decreased resistance to acid, hyperosmotic stress, heat, and desiccation. Additional associations include decreased autophagy, mitophagy, and mitotic recombination, as well as abnormal endoplasmic reticulum and lipid particle morphology. Studies of related genes in other species link the family to non-specific serine/threonine kinase activity.