TRX2 — Saccharomyces cerevisiae S288c

Summary

YGR209C, also known as TRX2, encodes a thioredoxin protein in Saccharomyces cerevisiae S288c on chromosome VII. The product possesses protein-disulfide reductase and antioxidant activities. TRX2 is associated with responses to oxidative stress and detection of oxidative stress, protein folding in the endoplasmic reticulum, cellular detoxification of hydrogen peroxide, and regulation of protein oxidation. It has been linked to hexose and methionine metabolism, glutathione metabolism, sulfate assimilation, glycosylation, and protein denaturation. The gene is associated with traits including biomass yield, respiration rate, and oxidative stress. Phenotypic associations include increased lifespan, altered oxidative stress resistance, increased heat sensitivity, changes in competitive fitness, abnormal vacuolar morphology, and altered resistance to chemicals. The protein localizes to the cytoplasm, cytosol, nucleus, vacuole, and mitochondria.