MGA1 — Saccharomyces cerevisiae S288c

Summary

YGR249W, also known as HSF1 or MGA1 on chromosome VII of Saccharomyces cerevisiae S288c, encodes a DNA-binding transcription activator with sequence-specific DNA binding activity. The protein belongs to the HSF family and is localized to the nucleus and chromatin. This gene is associated with diverse biological processes including sterol import, response to nutrient, MAPK cascade, apoptotic process, pseudohyphal growth, cellular thermotolerance, and response to cold. It is linked to oxidative stress and numerous phenotypes such as decreased pseudohyphal and filamentous growth, abnormal cell cycle progression, altered colony appearance, decreased anaerobic growth, increased invasive growth, decreased UV resistance, decreased heat sensitivity, and decreased vegetative growth. Related genes in other species are linked to reduced virulence.