GCN5 — Saccharomyces cerevisiae S288c

Summary

YGR252W, also known as GCN5, encodes a histone acetyltransferase that modifies histones H3 at lysines 9, 14, and 18, and also possesses peptide crotonyltransferase and histone crotonyltransferase activities. It is a transcriptional coactivator, chromatin adaptor, and histone reader, and is localized to the nucleus, chromatin, and the ADA, SALSA, and SAGA complexes. GCN5 is associated with transcription by RNA polymerase II, SAGA complex recruitment, cellular senescence, programmed cell death, DNA recombination, protein ubiquitination, and responses to oxidative stress. The gene is linked to traits including potassium concentration, phosphate and protein content, oxidative stress, and acid sensitivity. Phenotypic associations include decreased fermentative growth, increased flocculation, abnormal spindle and bud morphology, decreased sporulation, and altered respiratory growth and carbon source utilization. Studies of related genes in other species link the family to reduced virulence.