RAD2 — Saccharomyces cerevisiae S288c

Summary

YGR258C in Saccharomyces cerevisiae S288c encodes a protein with DNA endonuclease, single-stranded DNA endodeoxyribonuclease, 5'-3' exonuclease, and 5' flap endonuclease activities, along with DNA and metal binding. It belongs to the XPG/Rad2 family of structure-specific nucleases. The gene is associated with base excision repair, nucleotide excision repair, postreplication repair, DNA damage checkpoint signaling, meiotic heteroduplex formation, maintenance of DNA trinucleotide repeats, Okazaki initiator RNA removal, and mitochondrial DNA metabolism. It has been linked to cell cycle progression, vegetative growth, cell size, mutation frequency, and responses to UV, bleomycin, oxidative stress, and metals. Localization evidence places the product in the nucleus, nucleolus, nucleoplasm, cytoplasm, cytosol, and mitochondria. Studies of related genes in other species link the family to DNA repair and replication processes.